相关实验视频
Updated: May 7, 2026
06:15
Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
11.9K
在自我乳化系统中利用治疗性深层乳化溶剂,以改善CBD的输送
Gennaro Balenzano1, Giuseppe Francesco Racaniello1, Antonio Spennacchio1
1Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona, 4 I-70125, Bari, Italy.
International journal of pharmaceutics
|May 26, 2024
概括
这项研究开发了一种新型的治疗性深度浸泡溶剂 (THEDES),使用大麻二醇晶体 (CBD) 和酸 (CA). 由此产生的系统是自乳化药物输送系统 (SEDDS),增强了CBD的稳定性和口服输送.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 配方化学 配方化学 配方化学
背景情况:
- 大麻素 (CBD) 是一种BCSII类药物,溶解性差,限制了其口服生物利用性.
- 开发稳定和有效的输送系统对于提高治疗结果至关重要.
- 治疗性深层欧性溶剂 (THEDES) 为改善药物的溶解性和稳定性提供了一个有前途的方法.
研究的目的:
- 为了准备一个新的THEDES使用CBD和酸 (CA).
- 制定一种自乳化药物输送系统 (SEDDS),其中包括基于CBD的THEDES.
- 评估开发的SEDDS的物理稳定性,胃保护和体外性能.
主要方法:
- 使用烯酸制备基于CBD的THEDES.
- 通过FT-IR和NMR确认了结.
- 用表面活性剂和辅助表面活性剂配制SEDDS.
- 使用光散射技术评估物理稳定性.
- 在pH 1.2下评估胃稳定性.
- 在体外Caco-2细胞透性的研究.
主要成果:
- 一种稳定,疏水的CBD-THEDES成功地被制备出来.
- 在CBD-THEDES被有效地纳入SEDDS,形成统一的纳米乳液.
- 在压力条件下,SEDDS表现出极好的物理稳定性.
- 该配方在酸性环境 (pH 1.2) 中保护CBD免受降解2小时.
- 在体外研究证实了配方的安全性,并通过Caco-2细胞增强了CBD的透.
结论:
- THEDES是一种可行的策略,用于制备像CBD这样的溶性较差的药物.
- 基于脂质的配方,如SEDDS,可以有效地结合THEDES,以改善口服输送.
- 这种方法提供了一种新且强大的方法,可以通过口服方式提供CBD的治疗剂量.
相关概念视频
01:12Solvents
A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
A...
01:16Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
01:27Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:18Transdermal Drug Delivery Systems
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...