小型航空障碍和死亡率:来自英国生物银行的发现
Valentina Quintero Santofimio1, Ben Knox-Brown1, James Potts1
1National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Chest
|May 26, 2024
概括
小气道阻塞 (SAO) 与所有原因,心血管,呼吸道和癌症的死亡风险更高有关. 这种关联甚至适用于孤立的SAO,表明存在严重的健康问题.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 小气道阻塞 (SAO) 很普遍,与呼吸道症状,心脏代谢疾病和COPD进展有关.
- 在一般人群中,SAO对死亡率的预测值在很大程度上仍未确立.
研究的目的:
- 调查螺旋计定义的SAO与所有原因和疾病特异性死亡率之间的联系.
- 探索SAO-死亡率关系中的潜在性别差异.
主要方法:
- 对252,877名成年人 (40-69岁) 的英国生物库数据进行分析.
- 以FEV3/FEV6比率定义的SAO低于正常的下限;以正常FEV1/FEV6比率定义的孤立SAO.
- 多变量考克斯回归模型评估了死亡风险,重复分析排除了经常吸烟者.
主要成果:
- 在59,744名参与者中发现了SAO;在12.8年的中位随访期间发生了5,009例死亡.
- SAO与全因 (HR 1.31) 心血管 (HR 1.39) 呼吸系统 (HR 2.20) 和瘤 (HR 1.23) 死亡率的增加有关.
- 孤立的SAO也与较高的死亡率有关 (HR 1.14);关联并未因性别而改变,但在从未吸烟者中有所不同.
结论:
- 患有SAO的人面临全因和特异性死亡率的高风险.
- 需要进一步的研究来确定SAO是否是一种因果因素或潜在病理的标志物.
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