制备和持续释放含有不同功能组的芳香化合物的奇托-酸双层微囊
Shuai Wang1, Zhaohui Ren2, Helin Li2
1Flavor and Fragrance Engineering & Technology Research Center of Henan Province, College of Tobacco Science, Henan Agricultural University, Zhengzhou 450002, China.
International journal of biological macromolecules
|May 26, 2024
概括
这项研究开发了两层微囊,使用酸盐和酸来封装芳香化合物. 这些微囊表现出增强的稳定性和对醇,尤根醇,甲和酸的控制释放特性.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 药物运输 药物运输 药物运输
背景情况:
- Bilayer微囊提供了增强的稳定性和可控释放的活性化合物.
- 芳香化合物,如醇,eugenol, cinnamaldehyde,和酸有多种应用,但需要有效的封装,以保持稳定和可控的交付.
研究的目的:
- 为了合成和表征含有四种不同的芳香化合物的双层微囊.
- 评估开发的微囊的持续释放特性和热稳定性.
主要方法:
- 比莱尔微囊使用冷干燥方法合成,使用酸盐 (CS) 和酸盐 (ALG) 作为壁材料.
- 使用直角实验来优化微囊形成的CS度和质量比.
- 描述涉及富里埃变换红外光谱 (FTIR),扫描电子显微镜 (SEM),传输电子显微镜 (TEM) 和热重力度分析 (TGA).
主要成果:
- 确定了欧原醇封装的最佳条件:1.2%的CS剂量,1:2的CS与欧原醇比率和1:1的CS与ALG比率.
- FTIR,SEM和TEM证实了核心材料在稳定,球形双层结构中的成功封装.
- 热重力测量分析和持续释放研究表明,与自由核心材料相比,增强了热稳定性和降低了挥发性.
结论:
- 这项研究成功地准备了两层微囊,封装了醇,eugenol, cinnamaldehyde 和酸.
- 微囊表现出良好的持续释放特性,遵循第一阶动力学.
- 释放顺序被确定为醇 > 尤金醇 > 甲 > 酸,突出了它们在受控分娩应用中的潜力.
相关概念视频
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...