达--开通过抑制补体激活,LPS-TLR4 / NF-κB信号通路和NET形成来缓解性结肠炎
Yun Yang1, Lengqiu Guo2, Lan Wei1
1College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China.
达英 (DYY) 有效地治疗性结肠炎 (UC) 通过减少炎症和保护结肠. 这种传统中医药显示出作为UC患者治疗剂的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 达元 (Da-yuan-yin) (DYY) 是一种中国传统医学 (TCM) 处方,在性结肠炎 (UC) 治疗中曾经被使用过.
- 性结肠炎 (UC) 是一种慢性炎症性肠病,其特征是肠道炎症和屏障功能障碍.
研究的目的:
- 在小鼠模型中研究DYY对硫酸 (DSS) 诱导的UC的保护作用.
- 阐明DYY在UC治疗作用的潜在机制.
主要方法:
- 在小鼠中诱导了性结肠炎,使用2.5%的DSS7天.
- DYY是口服的,每天服用不同的剂量 (0.4,0.8,1.6g/kg) 连续7天.
- 进行了结肠组织的组织病理学检查和血清的生物化学分析.
主要成果:
- DYY显著降低了疾病活动指数 (DAI),结肠缩短和病理损伤.
- DYY恢复了肠道紧结蛋白的表达,并降低了脂多糖 (LPS),乳酸 (LA) 和循环自由DNA (cfDNA) 的水平.
- DYY抑制了炎症性细胞因子,补充激活,LPS-TLR4 / NF-κB信号传递,以及中性粒细胞外细胞陷 (NET) 的形成.
结论:
- DYY显示出对DSS诱导的UC显著的保护作用.
- 治疗机制包括调节炎症反应,抑制补体激活,LPS-TLR4 / NF-κB通路和NETs形成.
- DYY有潜力作为性结肠炎的治疗剂.
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