肠道微生物组和关节微生物组在患有膝关节关节炎的患者中显示出改变,与对照组相比:系统性审查
Ron Gilat1, Allen A Yazdi2, Alexander C Weissman2
1Midwest Orthopaedics at Rush University Medical Center, Chicago, Illinois, U.S.A.; Department of Orthopaedic Surgery, Shamir Medical Center and Tel Aviv University, Tel Aviv, Israel.
概括
膝关节骨关节炎 (OA) 患者的肠道和关节微生物组发生变化,影响疼痛,炎症和疾病进展. 这些发现强调了微生物组联合轴作为OA潜在的治疗点.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 整形外科 整形外科 整形外科
背景情况:
- 人类微生物群,特别是肠道微生物群,在维持宿主健康和调节生理过程方面发挥着至关重要的作用.
- 肠道微生物组的不平衡与各种慢性疾病有关,包括炎症和代谢疾病.
- 新出现的证据表明微生物组与关节健康之间存在联系,特别是在膝关节关节炎 (OA) 的情况下.
研究的目的:
- 系统地审查关于微生物组与膝关节骨关节炎 (OA) 之间的关系的科学文献.
- 专门研究肠道微生物组 - 关节轴和关节微生物组在膝关节OA病变发生中的作用.
- 综合当前关于微生物变化的知识,以及它们与OA相关结果的关联.
主要方法:
- 按照系统审查和元分析 (PRISMA) 准则的首选报告项目进行了系统审查.
- 在PubMed,Embase和Cochrane数据库中进行了英语临床研究的搜索.
- 包含的研究中的偏见使用非随机化研究 (MINORS) 方法指数评分来评估.
主要成果:
- 与对照人群相比,在膝盖骨关节炎患者中一致观察到肠道微生物组合的变化.
- 特定的肠道细菌与膝关节OA相关的疼痛,功能结果和成像发现有关.
- 在OA膝关节的突液中检测到了微生物,它们具有与OA发育和发病相关的独特特征.
- 关节微生物组的改变,包括增加的脂聚糖 (LPS) 和LPS结合蛋白,与OA的严重程度和疼痛相关.
结论:
- 肠道微生物组 - 关节轴和关节微生物组都在膝盖骨关节炎患者中表现出改变的微生物组成.
- 这些微生物变化与失调的代谢和炎症途径有关,影响OA的进展.
- 这些发现强调了准微生物组来管理膝关节骨髓炎症状和疾病进程的潜力.
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