在西班牙人口中,性酸酶的年龄和性别动态波动和参考间隔
Laura Castells Vilella1, Paula Sánchez-Pintos2,3,4,5, José Félix Muñiz Llama1
1From the Department of Pediatrics, Hospital Universitari General de Catalunya, Grupo Quirónsalud, Sant Cugat del Vallès, Barcelona, Spain (Castells Vilella, Muñiz Llama).
Archives of pathology & laboratory medicine
|May 26, 2024
概括
酸酸酶 (ALP) 水平随年龄和性别而波动,因人群而异. 建立特定的参考间隔对于准确的疾病诊断和早期发现异常至关重要.
科学领域:
- 生物化学 生物化学
- 临床化学 临床化学
- 儿科 儿科 儿科
背景情况:
- 性酸酶 (ALP) 活性解释对于诊断各种疾病至关重要.
- ALP水平在一生中呈现动态变化,并且在不同的人群中可能有很大的差异.
研究的目的:
- 在西班牙人口中建立ALP活动的参考间隔 (RIs) 和百分位数图表.
- 将这些新成立的RI与其他国家的RI进行比较.
主要方法:
- 一项多中心观测研究分析了662,350个年龄在0-99岁的人的ALP测量结果.
- 在2020年至2022年期间,从9个西班牙高等保健中心收集了数据.
- 这是迄今为止关于ALP活动的最大的公布数据集.
主要成果:
- 根据性别和年龄分层的ALP活动的连续百分位图表被开发为RI.
- 峰值ALP水平在生命的第一个星期被观察到,男孩和女孩有不同的青春期模式.
- 发现了显著的成人差异,男性 (20-49岁) 和女性 (50-79岁) 的水平更高.
结论:
- ALP活动表现出年龄和性别相关的波动和地理差异.
- 准确的人口特异性参考值对于正确的诊断解释至关重要.
- 实施适当的RI有助于早期诊断与ALP异常相关的疾病.
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