经过重症生存后疾病严重程度和身体功能变化之间的关联:一个多中心回顾性观察性研究
Keibun Liu1, Tomohiro Hamagami2, Naoki Sugiyasu3
1Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia; Non-Profit Organization ICU Collaboration Network (ICON), Tokyo, Japan.
概括
在ICU入院后48小时内疾病严重程度的变化,通过顺序器官衰竭评估 (SOFA) 评分来衡量,比单次评估更好地预测出院时的身体功能障碍. 早期恶化表明恢复较差.
科学领域:
- 关键护理医学 关键护理医学
- 神经学 神经学
- 康复医学 康复医学 康复医学
背景情况:
- 疾病的严重程度显著影响患者的功能结果.
- 预测功能障碍的程度一直是不一致的.
- 早期评估严重疾病的严重程度对于患者管理至关重要.
研究的目的:
- 为了确定在ICU入院后48小时内疾病严重程度的变化是否比单次评估更好地预测身体功能障碍.
- 为了调查早期变化之间的关联 序列器官衰竭评估 (SOFA) 评分和在医院出院时的身体功能.
主要方法:
- 在日本199名成年ICU患者的多中心回顾性研究.
- 在医院出院时使用巴特尔指数评估身体功能.
- 分析了巴特尔指数和在ICU入院时的SOFA得分之间的关联,在48小时内达到峰值的SOFA,以及这些得分之间的变化.
主要成果:
- 48小时内最高的SOFA分数和SOFA分数的变化与下降的巴特尔指数分数显著相关.
- 在48小时内,SOFA得分增加1分或以上,预测巴特尔指数得分为60分或以下.
- 在ICU入院时的SOFA得分和巴特尔指数得分之间没有发现显著的关联.
结论:
- 在ICU停留的前48小时内,SOFA分数的变化比单次入院评估更能预测出院时的身体功能障碍.
- 早期ICU住院中SOFA分数的恶化可能表明危急疾病后恢复潜力降低.
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