产生毒素的Clostridioides difficile与小猪腹的关联以及可能传播给人类的可能性
Kouki Takeichi1, Akira Fukuda1, Chika Shono2
1Laboratory of Food Microbiology and Food Safety, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
The Journal of veterinary medical science
|May 26, 2024
概括
克洛斯特里迪奥伊德困难毒素的存在与小猪腹有关,尽管总体细菌水平没有差异. 超病毒性菌株正在全球范围内在猪和人类之间传播.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物健康 动物健康
- 传染性疾病 传染性疾病
背景情况:
- 困难菌 (C. difficile) 对小猪健康的作用尚未完全理解.
- 控制C. difficile对小猪福利的影响需要进一步调查.
研究的目的:
- 调查C. difficile存在与小猪腹之间的关联.
- 通过使用全基因组测序来确定来自猪和人类的C. difficile分离物的遗传关系.
主要方法:
- 在日本五个农场收集了有和没有腹的猪的便样本.
- 全基因组测序 (WGS) 的C. difficile分离来分析遗传关系.
- 猪衍生分离物与人类临床和国际动物衍生菌株的比较.
主要成果:
- 毒素阳性C. difficile菌株在经历腹的小猪中更常见.
- 在腹和非腹的小猪之间没有观察到C. difficile总体流行率的显著差异.
- 全基因组测序显示,日本猪C. difficile ST11 (包括高病毒性PCR核型078) 基因与国际菌株和日本人类分离物相似.
结论:
- 生产毒素的C. difficile可能会导致小猪的腹.
- 过度病毒性C. difficile菌株在猪和人类种群中显示出全球传播.
- 需要进一步的研究来确认因果关系,并确定其他导致小猪腹的因素.
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