经过小部神经内分泌瘤的微创手术后的长期生存结果
Akitada Yogo1,2, Alan Paciorek2,3, Yosuke Kasai4
1Division of Surgical Oncology, Section of Hepatopancreaticobiliary Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Annals of surgical oncology
|May 26, 2024
概括
最少侵入性手术 (MIS) 的长期存活预期与对伊莱尔神经内分泌瘤 (i-NETs) 的开放性手术相似. MIS是一种可行的替代方案,尽管对于体积较大的人群或同时切除肝脏,可以选择开放式手术.
科学领域:
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 皮质神经内分泌瘤 (i-NETs) 经常存在多焦点性疾病和大中腔体质量.
- 之前的研究表明,在i-NET中,微创手术 (MIS) 的短期结果是有利的.
- 这项研究旨在评估MIS对i-NETs的长期生存结果.
研究的目的:
- 为了比较微创手术 (MIS) 的长期存活结果与以利亚神经内分泌瘤 (i-NETs) 的开放手术.
- 确定潜在的标准,指导在MIS和i-NET切除的开放手术之间做出选择.
主要方法:
- 对168名患者进行了回顾性研究,这些患者在2007年至2023年期间接受了初级i-NET切除.
- 根据治疗意图,患者被分为MIS和开放手术组.
- 倾向性得分匹配 (PSM) 和考克斯回归被用于分析整体存活率,旨在最大限度地减少混变量.
主要成果:
- 129名患者 (77%) 接受了MIS,其中27人转换为开放手术.
- 随访时间中位数为49个月.
- 在PSM队列中,在MIS和开放手术之间没有观察到总生存时间的显著差异 (中位数为99个月与103个月,p=0.77).
结论:
- 最少侵入性手术 (MIS) 是对大肠神经内分泌瘤 (i-NETs) 的开放性手术的安全和有效替代方案,产生类似的瘤结果.
- 庞大的介质质量和需要同时切除肝脏的需要是选择开放性手术的潜在指标.
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