有机酸减轻了Streptococcus agalactiae在鱼肠道初级细胞和肠道感染模型中的毒性
Petculescu Ciochina Liliana1, Gabi Dumitrescu1, David McCleery2
1Faculty of Bioengineering of Animal Resources, University of Life Sciences King Mihai I from Timisoara, Timisoara, 300645, Romania.
Irish veterinary journal
|May 26, 2024
概括
有机酸的混合物,AuraAqua,有效地打击了小鱼的Streptococcus agalactiae感染. 这种天然的抗微生物降低了鱼类中的细菌毒性和炎症,为水产养殖中抗生素提供了一个有希望的替代品.
科学领域:
- 水生微生物学 水生微生物学
- 鱼类免疫学 鱼类免疫学
- 抗微生物研究的研究.
背景情况:
- 杆菌 (Streptococcus agalactiae) 是水产养殖中的重要病原体,导致养殖鱼类的高死亡率.
- 抗生素替代品是必要的,但它们的作用机制需要进一步的科学研究.
研究的目的:
- 调查AuraAqua (Aq) 有机酸混合物对Streptococcus agalactiae毒性的疗效.
- 阐明Aq在对抗鱼中S. agalactiae感染的作用模式.
主要方法:
- 利用了肠初级上皮细胞和体外肠培养模型.
- 评估了Aq对S. agalactiae感染水平和与细菌毒性和鱼类免疫反应相关的基因表达的影响.
主要成果:
- AuraAqua显著降低了S. agalactiae在鱼肠道细胞和组织中的水平.
- Aq降低细菌囊多糖化物 (CPS) 基因表达,降低表面囊产量.
- Aq减少了受感染的西虫组织中促炎性基因表达 (IFNγ,IL1β,TNFα) 和H2O2的产生.
结论:
- 像AuraAqua这样的有机酸混合物显示出在水产养殖中治疗S. agalactiae感染的抗生素的天然替代品的潜力.
- Aq有效地减轻了S. agalactiae感染和与其相关的炎症在鱼的消化道.
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