在COVID-19大流行期间,血液恶性瘤患者的呼吸道感染趋势的变化
Jiwon Ryoo1, Seok Chan Kim2, Jongmin Lee3
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
BMC pulmonary medicine
|May 26, 2024
概括
由于COVID-19大流行,在患有血液恶性瘤 (HM) 的患者中减少了社区病毒性肺炎 (CAP). 细菌和真菌CAP发病率保持不变,但较高的器官衰竭得分和低血小板数量增加了死亡风险.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- COVID-19 流行病改变了全球呼吸道感染模式.
- 它对高风险血液恶性瘤 (HM) 患者的社区获得性肺炎 (CAP) 的具体影响尚不清楚.
研究的目的:
- 在COVID-19大流行期间调查HM患者中CAP病因学的变化.
- 在这个患者队列中确定住院死亡风险因素.
主要方法:
- 在2018年3月至2022年2月期间,对524名HM患者进行了回顾性研究,这些患者在2018年3月至2022年2月期间住院治疗CAP.
- 包括在入院后24小时内接受支气管镜检查的患者.
- 分析了患者特征,实验室发现,支气管支气管洗液培养物和PCR测试,比较COVID-19前和COVID-19时代.
主要成果:
- 与COVID-19前的时代相比,COVID-19时代的病毒性CAP发生率显著下降 (例如,A型流感,偏流感,腺病毒,鼻病毒).
- 细菌,真菌和未知的CAP病因的发病率在两个时期之间保持不变.
- 较高的序列器官衰竭评估得分和较低的血小板计数与增加的住院死亡率有关.
结论:
- 由于COVID-19大流行,HM患者的病毒性CAP显著下降,而细菌或真菌CAP没有显著变化.
- 需要进一步的研究来了解COVID-19对CAP的HM患者预后的全部影响.
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