一些基异环的抗菌潜力的最新发展及其SAR研究:一篇综述
Bhupender Nehra1, Manoj Kumar1, Sumitra Singh1
1Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana, India.
Current medicinal chemistry
|May 27, 2024
概括
基异环衍生物显示出作为新型抗菌剂的前景,用于打击耐药性和减少副作用. 本综述强调了它们的结构特征和药理作用,用于开发新的化合物.
科学领域:
- 药用化学 医学化学
- 药物发现 药物发现 药物发现
- 药理学 药理学是指药理学的学科.
背景情况:
- 传染病对全球健康构成重大威胁,抗菌素耐药性增加使治疗复杂化.
- 目前的抗微生物疗法因副作用,毒性和微生物耐药性而面临挑战.
- 含的异环基架在药物发现中至关重要,用于开发更强效,更安全的抗微生物药物.
研究的目的:
- 审查最近 (2015-2023) 含有的异环素 (皮拉,皮拉,伊米达,四,素) 的抗菌潜力.
- 总结用于抗微生物应用的基异环衍生物的药物化学进步.
- 为了将结构特征与药理作用相关联,包括在和机械学研究中,用于化合物生成.
主要方法:
- 在体外和体内微生物抗菌结果的基异环分子的分析.
- 使用in silico计算分析进行结构-活动关系 (SAR) 预测.
- 关于抗微生物基异环衍生物的最新文献的综述.
主要成果:
- 含的异环在天然和合成化合物中表现出不同的抗菌作用.
- 越来越需要新的基异环分子来解决微生物耐药性的问题.
- 针对性的选择性和特异性是新抗菌剂的关键.
结论:
- 基于异环的新型抗微生物药物对于克服耐药性和最大限度地减少副作用至关重要.
- 了解结构单元和抗菌作用之间的联系对于开发有效药物至关重要.
- 本综述为设计新的抗微生物化合物提供了对结构-活性关系的见解.
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