身体形障碍患者与健康个体之间,相同任务的学习受到实质上不同的机制的支持,身体形障碍患者和健康个体之间的学习
Zhiyan Wang1,2, Qingleng Tan1, Sebastian M Frank1,2
1Department of Cognitive, Linguistic and Psychological Sciences, Brown University, 190 Thayer Street, Providence, RI 02912, United States.
Cerebral cortex (New York, N.Y. : 1991)
|May 27, 2024
概括
患有身体形障碍 (BDD) 的个体在视觉任务训练后,与健康个体相比,显示出不同的大脑活动变化. 这些独特的神经机制可能是BDD的适应.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 视觉感知 视觉感知 视觉感知
背景情况:
- 在精神疾病中观察到视觉处理的改变.
- 在这些疾病中,潜在的感知学习的神经机制仍然不清楚.
- 身体形障碍 (BDD) 涉及对感知到的身体缺陷的关注.
研究的目的:
- 调查BDD患者是否与健康对照者相比使用类似的神经元机制来进行视觉感知学习.
- 在视觉面部检测任务期间检查大脑激活和功能连接的变化.
主要方法:
- 功能磁共振成像 (fMRI) 用于测量大脑激活.
- 患有BDD和健康对照的患者接受了视觉检测任务的培训,该任务涉及低空间频率的面孔.
- 在行为训练之前和之后进行了fMRI扫描.
主要成果:
- 两组的任务表现都得到了类似的改善.
- 状面部区域 (FFA) 的神经元变化不同:激活在BDD患者中增加,但在低空间频率面部的对照中减少.
- 在培训后的BDD患者中,FFA内的功能连接性下降,而在对照组中增加.
结论:
- 面部检测感知学习的神经机制在BDD患者和对照人群之间存在根本的差异.
- 在BDD患者中,FFA激活和连接的改变可能代表大脑对疾病的适应.
- 这些发现有助于了解视觉处理改变的精神疾病的神经基础.
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