伴随性疾病对前列腺癌特定死亡率的影响:基于人口的队列研究
Tenaw Tiruye1,2, David Roder1, Liesel M FitzGerald3
1Cancer Epidemiology and Population Health Research Group, Allied Health and Human Performance, University of South Australia, Adelaide, Australia.
伴随性疾病显著影响前列腺癌的生存率. 三种或以上的疾病,包括心脏病和慢性呼吸道疾病,增加死亡风险,突出需要全面的并发症管理.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 伴随性疾病在前列腺癌患者中很常见.
- 伴随性疾病对前列腺癌死亡率的影响需要进一步调查.
研究的目的:
- 评估伴随性疾病对前列腺癌死亡率的影响.
- 为了确定与前列腺癌死亡率增加相关的特定并发症.
主要方法:
- 分析了15695名被诊断患有前列腺癌的南澳大利亚男性的队列 (2003-2019).
- 在诊断前一年使用Rx风险指数测量并发症.
- 灵活的参数竞争风险回归被用于分析与前列腺癌特异性死亡率的关联,调整为共变量.
主要成果:
- 3或更高的Rx风险得分与前列腺癌特异性死亡率的增加有关 (sHR 1.34).
- 特定的并发症,包括心脏病,慢性呼吸道疾病,抑郁症/焦虑症和血栓形成,与较高的死亡率有关.
- 对心脏病 (sHR 1.31),慢性呼吸道疾病 (sHR 1.20),抑郁/焦虑 (sHR 1.17) 和血栓形成 (sHR 1.21) 的药物使用增加了死亡风险.
结论:
- 有三种或更多的并发性疾病显著增加前列腺癌死亡风险.
- 特定的并发症,如心脏病,慢性呼吸道疾病,抑郁症/焦虑症和血栓形成,独立地与较差的前列腺癌存活率有关.
- 这些并发症的有效管理可能会改善前列腺癌患者的生存结果.
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