在成年人生长激素治疗期间探索心血管风险的性别差异
Tessa N A Slagboom1,2, Aart Jan van der Lely3, Madeleine L Drent1,2
1Department of Endocrinology and Metabolism, Amsterdam UMC, Vrije Universiteit, 1081 HV, Amsterdam, The Netherlands.
European journal of endocrinology
|May 27, 2024
概括
与女性相比,生长激素缺乏症 (GHD) 的男性在身体组成和胆固醇水平方面从GH替代疗法 (GHRT) 中获得的早期好处更大. 然而,在治疗期间,在心血管疾病风险方面没有出现性别差异.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 心血管 (CV) 发病率和死亡率的性别差异存在于接受GH替代疗法 (GHRT) 的生长激素缺乏 (GHD) 患者中.
- 之前的研究表明,两性之间治疗疗效的潜在差异.
研究的目的:
- 调查GHD成年人的CV风险概况和疾病的长期GHT疗效的性别特异性差异.
- 为了测试假设,女性体验的GHRT的益处效果比男性少.
主要方法:
- 全国回顾性队列研究.
- 来自荷兰国家成人GH治疗注册表的1335名男性和1251名女性严重GH的比较.
- 在基线和随访期间评估心血管风险概况和发病率.
主要成果:
- 在基线时,男性呈现出更不利的CV风险概况.
- 在GHRT的最初几年中,在男性中观察到腰围,腰比,总胆固醇和甘油三的较大减少 (P < .05).
- 在GHRT期间,在发生非致命心血管或脑血管疾病的风险方面没有发现任何显著的性别差异.
结论:
- 与女性相比,患有GHD的男性表现出更明显的身体组成和脂蛋白代谢在GHRT的早期改善.
- 尽管基线差异,但GHT并没有导致CV和脑血管发病风险的性别特异差异.
相关概念视频
Hormonal Regulation of Blood Pressure
2.6K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.6K
Signs of Puberty
328
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
328
Hormonal Regulation
43.4K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.4K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
138
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
138
Regulation of the Cardiovascular System
1.1K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
1.1K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
77
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
77


