一种新的预期最大化方法,从时间序列遗传数据推断出一般双体选择
Adam G Fine1,2, Matthias Steinrücken1,3
1Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA.
bioRxiv : the preprint server for biology
|May 27, 2024
概括
量化遗传选择是人口遗传学的关键. 这项研究引入了一种新方法,用于从时间序列遗传数据中检测一般双胞胎选择,改进了假定附加选择的模型.
科学领域:
- 人口遗传学 人口遗传学
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 检测和量化选择强度是人口遗传学的首要目标.
- 现有的方法往往假定附加性选择,忽视非附加性遗传变异.
- 在一般的双倍体模型下表征选择对于全面理解进化至关重要.
结论:
- 这项工作介绍了第一个全基因组扫描,能够表征一般双胞胎选择信号.
- 开发的方法提供了一个更全面的方法来理解由选择驱动的进化过程.
- 未来的研究可以利用这个框架来探索各种人群中多样化的选择机制.
相关概念视频
Genetics of Speciation
19.2K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
19.2K
Hardy-Weinberg Principle
72.1K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
72.1K
Frequency-dependent Selection
22.0K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
22.0K
Chi-square Analysis
38.2K
The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
38.2K
Types of Selection
40.4K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
40.4K
Mutation, Gene Flow, and Genetic Drift
58.3K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
58.3K


