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Updated: Jun 25, 2025

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
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KBTBD4 癌症热点突变驱动HDAC1/2核心压缩机复合体的新形降解

Xiaowen Xie, Olivia Zhang, Megan J R Yeo

    bioRxiv : the preprint server for biology
    |May 27, 2024
    PubMed
    概括

    在 KBTBD4 中的癌症突变通过导致 CoREST 的异常降解来驱动脑髓母细胞瘤. 这项研究揭示了突变如何与HDAC1/2产生新的相互作用,为儿科脑瘤提供治疗点.

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