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Updated: Jun 25, 2025

Differentiation of Human Pluripotent Stem Cells Into Pancreatic Beta-Cell Precursors in a 2D Culture System
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Published on: December 16, 2021

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ALDH3B2的功能丧失将人类胰腺管细胞转化为类似β细胞

Jian Li, Kevin Bode, Yu-Chi Lee

    bioRxiv : the preprint server for biology
    |May 27, 2024
    PubMed
    概括

    科学家们发现,禁用ALDH3B2基因可以将人类胰腺管细胞转化为功能性β类细胞. 这一突破为治疗糖尿病的β细胞再生提供了潜在的新策略.

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    Forced Transdifferentiation01:28

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    Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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