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在乌干达,与艾滋病毒感染者生活的老年人中,功能障碍的患病率更高

Amutuhaire Judith Ssemasaazi¹, Robert Kalyesubula¹, Yukari C Manabe²

¹Makerere University College of Health Sciences.

Research square

|May 27, 2024

概括

与未感染艾滋病毒的人相比,与艾滋病毒感染的老年人相比,艾滋病毒感染的老年人患功能障碍的比例显著更高. 在这种人群中,早期监测脏健康对于预防疾病进展至关重要.

科学领域:

老年学是一门学科.
传染性疾病传染性疾病
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

艾滋病毒感染者 (PLWH) 面临由于艾滋病毒,抗逆转录病毒疗法 (ART),糖尿病和高血压导致功能障碍的风险增加.
随着年龄的增长,功能自然会下降,这可能会加剧老年人慢性病 (CKD) 的负担.
关于老年PLWH与撒哈拉以南非洲艾滋病毒未感染个体的功能障碍患病率的数据有限.

研究的目的:

为了比较患有艾滋病毒的老年人与没有艾滋病毒的老年人中功能障碍的患病率,在乌干达坎帕拉.
在这个人口群体中确定与功能障碍相关的因素.

主要方法:

在乌干达坎帕拉进行了一项横截面研究,将60岁以上的艾滋病毒感染者和没有艾滋病毒感染者匹配起来.
收集的数据包括社会人口统计数据,并发病情况和HIV特定的临床细节.
功能障碍被定义为eGFR<60毫升/分钟/1.73米2,有或没有蛋白尿.

主要成果:

这项研究招募了278名参与者 (平均年龄66岁);50%是PLWH.
整体功能障碍的患病率为23.0%,在PLWH (33.1%) 显著高于未感染HIV的个体 (12.9%).
携带艾滋病毒 (OR=3.89),年龄较大 (OR=1.13),女性性别 (OR=1.95) 和高血压 (OR=2.19) 与功能障碍有关.

结论:

艾滋病毒感染是老年人功能障碍的重要危险因素.
建议在老年PLWH患者中定期监测功能和蛋白尿,以进行早期检测和管理.
干预措施,以减少病在这个脆弱的人群的进展是必不可少的.

关键词:

老年人年龄较大的人功能受损功能受损功能受损撒哈拉以南非洲地区.

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