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胎盘疟疾诱导了与胎儿生长限制相关的独特甲基化概况
bioRxiv : the preprint server for biology
|May 27, 2024
概括
胎盘疟疾 (PM) 在胎儿生长限制 (FGR) 中显著改变胎盘DNA甲基化. 与非疟疾FGR相比,PM-FGR显示了不同的表观遗传特征,揭示了对妊娠并发症的新见解.
科学领域:
- 生殖生物学 生殖生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 全球健康 全球健康
背景情况:
- 胎儿生长限制 (FGR) 会导致不良的出生结果和长期的健康问题.
- 胎盘表观遗传变化可能会将FGR与以后的生活并发症联系起来.
- 胎盘疟疾 (PM) 是FGR的主要原因,对胎盘表观遗传有未知的影响.
研究的目的:
- 研究非疟疾FGR与PM相关的FGR之间的胎盘甲基组差异.
- 在FGR亚型中识别共同和独特的表观遗传路径.
主要方法:
- 使用Infinium MethylationEPIC v1微阵列分析了胎盘DNA甲基化.
- 来自美国 (没有疟疾) 和乌干达 (高疟疾) 队伍的胎盘进行比较.
- 包括FGR和健康对照病例,PM通过组织病理学诊断.
主要成果:
- 非疟疾FGR与65种不同甲基化CpG (DMC) 相关;PM-FGR与133种DMC相关.
- 在两组FGR中都发现了一种常见的低甲基化DMC (cg16389901在BMP4促进剂中).
- 在非疟疾FGR和PM-FGR胎盘之间确定了522个DMC.
结论:
- 带有PM相关的FGR的胎盘表现出不同的DNA甲基化概况.
- 表明独特的表观遗传重编程在怀孕期间对疟疾的反应.
- 需要进一步的研究来澄清PM相关的FGR的长期健康结果.
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