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Updated: Jun 25, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

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H3F3A K27M 突变通过调节染色质可访问性来驱动压制性转录组,独立于 H3K27me3 在分散的中线质瘤中

Suraj Bhattarai, Faruck L Hakkim, Charles A Day

    bioRxiv : the preprint server for biology
    |May 27, 2024
    PubMed
    概括

    扩散中线质瘤 (DMG) 中的H3.3K27M突变改变了独立于H3K27甲基化的染色质可访问性,推动了瘤的发展. 这种PRC2独立的功能对质生成至关重要,并提出了新的治疗点.

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