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Updated: Jun 25, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Published on: July 17, 2020

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在体内针对PTPN11驱动型白血病中的MEK和TNK2/SRC通路

Bill H Chang, Karina Thiel-Klare, Jeffrey W Tyner

    bioRxiv : the preprint server for biology
    |May 27, 2024
    PubMed
    概括

    结合MEK和TNK2 / SRC抑制剂显示出治疗PTPN11突变白血病如JMML和AML的前景. 这种双重治疗在临床前模型中表现出显著的疗效,提供了潜在的新治疗途径.

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