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Updated: Jun 25, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
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由胆固醇积累引起的细胞衰老是由APOE4和AD中的 lysosomal ABCA1介导的

Shaowei Wang1, Boyang Li1, Zhiheng Cai1

  • 1University of Southern California.

Research square
|May 27, 2024
PubMed
概括

在阿尔茨海默病 (AD) 和APOE4模型中,胆固醇的积累通过将ATP结合盒载体A1 (ABCA1) 捕获在 lysosomes中,激活mTORC1通路,从而驱动细胞衰老. 降低胆固醇可以缓解这一过程,提供治疗见解.

关键词:
在ABCA1中,ABCA1是ABCA1.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.胆固醇 胆固醇 胆固醇 是一种lysosome 溶解酶体是如何形成的衰老是一种老化.

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