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Updated: Jun 25, 2025

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

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罗塞特Array®是人类神经发育风险定量高通量查平台

Brady F Lundin1,2,3, Gavin T Knight3,4, Nikolai J Fedorchak4

  • 1Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53705, USA.

bioRxiv : the preprint server for biology
|May 27, 2024
PubMed
概括

罗塞特Array平台提供了一个可扩展的方法来研究人类神经发育障碍,使用神经器官. 这种96井板测定使得药物发现和理解疾病原因的高通量查成为可能.

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Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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