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磁性引导的细胞疗法用于降低眼内压力,作为对开放角度玻璃眼瘤的治疗策略

M Reza Bahrani Fard, Jessica Chan, A Thomas Read

bioRxiv : the preprint server for biology

|May 27, 2024

概括

磁细胞疗法使用人类脂肪衍生的介质干细胞 (hAMSCs) 显著降低了眼内压力九个月在青光眼的小鼠模型. 这种新的方法对治疗眼睛高血压有希望.

科学领域:

眼科医生眼科眼科
再生医学是一种再生医学.
生物技术是生物技术.

背景情况:

玻璃眼瘤是不可逆转失明的主要原因,其特征是眼内压力升高 (IOP).
脊柱状网状 (TM) 细胞疗法是一种潜在的新一代玻璃眼治疗方法.
目前的治疗方法往往有局限性,需要创新的治疗策略.

研究的目的:

为了评估磁性引导细胞疗法的有效性,以减少青光眼的小鼠模型中的IOP.
为了比较人类脂肪衍生的介质干细胞 (hAMSCs) 和诱导多能干细胞衍生的TM细胞 (iPSC-TM细胞) 的治疗潜力.

主要方法:

在小鼠绿眼瘤模型中,使用磁性细胞控制来精确地将hAMSCs和iPSC-TM细胞传递到虹膜角膜角度.
在单细胞剂量后,对眼内压进行了长期监测.
评估了TM和外流通路功能中的细胞性.

主要成果:

一次剂量1500个磁转向的hAMSCs导致持续的4.5mmHg (27%) IOP降低9个月.
hAMSC治疗增加了传统的外流和TM细胞性,细胞可在三周内检测到.
iPSC-TM细胞显示出较小的内血压降低 (1.9 mmHg,13%),并携带较高的瘤性风险.

结论:

磁转向的hAMSC细胞疗法提供了一个有前途的,长期的解决方案,用于控制高血压在青光眼.
降低内血压的机制很可能是由被输送的细胞传递的膜信号介导的.
这项研究支持hAMSC治疗在治疗眼睛高血压的临床转化中的潜力.

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