免疫反应对重复流感疫苗接种暴露 (DRIVE I) 研究的动力学初步发现:随机对照试验
Benjamin J Cowling1,2, Sook-San Wong1,3, Jefferson J S Santos4
1WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
medRxiv : the preprint server for health sciences
|May 27, 2024
概括
每年接种流感疫苗可能会影响当前季节的有效性. 这项研究发现,重复接种疫苗的人对某些菌株的抗体反应较低,尽管在前两年,临床保护仍然相似.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 每年接种流感疫苗的有效性可能会受到之前接种疫苗的历史的影响.
- 机制尚不清楚,可能涉及免疫反应"专注"于较老的菌株.
结论:
- 在最初的两年中,重复接种和首次接种疫苗的患者表现出可比的疫苗接种后几何平均标位,这表明临床保护类似.
- 第二年的菌株更新允许未来探索人类免疫反应中的抗原距离.
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