提高MMP-9的调节可以预测内血管血栓切除术后的出血转变
Jin-An Huang1,2, Yu-Hsuan Wu1, Po-Lin Chen1,3,4
1Department of Neurology, Neurological Institute Taichung Veterans General Hospital, Taichung, Taiwan.
Frontiers in neurology
|May 27, 2024
概括
血管内血栓切除术 (EVT) 后矩阵金属蛋白酶-9 (MMP-9) 水平升高可能预测急性缺血性中风 (AIS) 患者的出血转化 (HT). 监测MMP-9可以帮助识别患有这种严重并发症风险的患者.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 临床医学 临床医学
背景情况:
- 出血转化 (HT) 是急性缺血性中风 (AIS) 血管内血栓切除术 (EVT) 后的一个重大并发症.
- 确定HT的预测生物标志物对于EVT后的患者管理至关重要.
研究的目的:
- 调查血矩阵金属蛋白酶-9 (MMP-9) 水平与AIS患者在EVT后出现HT的相关性.
- 评估MMP-9水平的时间变化及其对HT的预测值.
主要方法:
- 血MMP-9水平使用ELISA测量在30名AIS患者在EVT前和之后立即.
- 计算了EVT后MMP-9水平的百分比变化,并将发展HT的患者与没有发展HT的患者进行比较.
主要成果:
- 在30名AIS患者中,16名 (53.3%) 患有HT.
- 与没有HT的患者相比,HT患者在EVT后的动脉MMP-9水平的百分比增加显著更大.
- NIHSS得分表明症状严重程度,HT患者在入院和EVT后的得分高于没有HT的患者.
结论:
- 在EVT后动脉MMP-9水平升高与AIS患者的HT发展有显著的关联.
- 在EVT后MMP-9的升调可能作为出血转变的预测生物标志物.
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