研究中度至重度睡眠阻塞性呼吸暂停和认知障碍,焦虑和抑郁之间的关系
Yanan Hong1, Chong Pei1, Lingli Hao1
1Department of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, China.
Frontiers in neurology
|May 27, 2024
概括
中度至重度的阻塞性睡眠呼吸暂停 (OSA) 与认知能力下降以及抑郁和焦虑的增加有关. 这些问题与睡眠呼吸暂停严重程度和氧气不和有关,焦虑独立影响认知功能.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的疾病,与各种健康问题有关.
- 在OSA患者中经常观察到认知障碍,抑郁症和焦虑症.
- 了解OSA严重程度与认知/情绪健康之间的相互作用对于有效管理至关重要.
研究的目的:
- 为了研究阻塞性睡眠呼吸暂停 (OSA) 严重程度和认知功能之间的关系.
- 为了检查OSA患者中抑郁和焦虑的患病率.
- 确定影响OSA患者认知功能的因素.
主要方法:
- 102名患者被分为没有/轻度OSA和中度/重度OSA组,基于多睡眠学 (PSG).
- 认知功能使用蒙特利尔认知评估 (MoCA),Stroop颜色和文字测试 (SCWT) 和数字跨度测试 (DST) 来评估.
- 抑郁和焦虑水平使用自评抑郁量表 (SDS) 和自评焦虑量表 (SAS) 进行测量.
主要成果:
- 中度至重度的OSA患者表现出更高的BMI,子周长,睡眠效率低下,焦虑 (SAS) 和抑郁 (SDS) 分数.
- 视觉空间功能,执行功能,记忆,语言和定向方面的认知缺陷在中度/严重的OSA组中更为明显.
- 摩卡总得分与年龄,呼吸暂停-呼吸暂停指数 (AHI),BMI,睡眠效率低下,SAS,SDS和缺氧负担 (CT90%,AHT90%,HAD) 有负相关.
结论:
- 中度至重度的OSA与显著的认知障碍和增加的抑郁和焦虑率有关.
- 认知功能受到OSA严重程度,氧和水平 (LSaO2,平均O2和) 和相关因素 (如AHI) 的影响.
- 焦虑,与OSA结合,独立地导致认知障碍,突出了综合治疗方法的需要.
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