产科抗脂综合征带有产科和血栓性并发症的终身风险增加 - 一项基于人口的研究
Ariel Katherine Rhein1, Anat Rabinovich2, Ran Abuhasira1,3
1The Joyce & Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
产妇抗脂综合征 (OAPS) 患者面临更高的血栓事件和妊娠并发症的风险,即使在治疗. 血栓性APS (TAPS) 患者也表现出患孕前的风险增加. 为了最佳的患者管理,需要进一步的研究.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 生殖免疫学 生殖免疫学
背景情况:
- 抗脂综合征 (APS) 呈现为血栓性APS (TAPS) 或产科APS (OAPS),对长期并发症的数据有限.
- 了解与OAPS和TAPS相关的独特风险对于患者护理至关重要.
研究的目的:
- 为了比较TAPS和OAPS表型之间的产科史,抗脂抗体配置文件,并发症和怀孕结果.
- 与一般产科患者相比,评估OAPS和TAPS患者中血栓和产科并发症的风险.
主要方法:
- 在1998年至2020年期间,对116,409名分娩单独怀孕的妇女进行了回顾性队列研究.
- 包括71名APS患者 (49名OAPS,22名TAPS),将他们的结果与整体产科人口进行比较.
- 分析了人口统计,产科,新生儿和血栓结局.
主要成果:
- 与普通人群相比,OAPS患者患血栓事件的风险显著增加 (OR 18.0).
- 尽管接受了抗血栓治疗,但OAPS患者患有与胎盘相关的和新生儿并发症的风险增加,包括晚期胎儿损失,死胎,胎盘断裂,孕前,FGR,SGA和低Apgar分数.
- 在TAPS患者中,孕前的风险增加 (aOR 3.1).
结论:
- 即使在标准治疗中,OAPS患者患血栓事件和产科并发症的风险增加.
- 此外,TAPS患者也面临更多的产科风险,尤其是孕前.
- 研究结果强调,需要对APS患者采取谨慎的管理策略,并在前性研究中进行验证.
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