无法逆转的影响的神经毒性综合征:一个范围审查
Koen Konieczny1, Johan Detraux1, Filip Bouckaert1
1University Psychiatric Center KU Leuven, Kortenberg, Belgium.
Alpha psychiatry
|May 27, 2024
概括
非可逆影响神经毒性综合征 (SILENT) 导致持续的神经问题,主要是小脑功能障碍. 尽管有几十年的报道,但知识仍然有限,需要进一步的研究来理解和预防这种罕见的并发症.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 无可逆转的影响神经毒性综合征 (SILENT) 是一种罕见但严重的中毒的神经并发症.
- 尽管自20世纪60年代以来被公认,但对SILENT及其长期神经系统后果的理解仍然有限.
- 之前的审查是叙事性的,强调需要对现有研究进行全面评估.
研究的目的:
- 进行范围审查,评估研究文献关于毒性的长期神经系统后果.
- 确定关于不可逆转影响神经毒性综合征 (SILENT) 的当前知识水平.
- 提取关于SILENT的临床表现,风险因素和潜在管理策略的关键信息.
主要方法:
- 在MEDLINE,Embase和Web of Science数据库 (开始至2023年7月) 进行了系统的文献搜索.
- 包括英语和荷兰语的文章,重点关注中毒的长期神经系统后果.
- 从117个案例中提取了91篇审查文章中的信息.
主要成果:
- 持续的小脑功能障碍是最常见的结果 (77%的病例),通常与其他神经系统缺陷同时发生.
- 其他常见的后果包括认知障碍,帕金森症,胆症,晚期动症和外围神经病变.
- 意识变化 (昏迷至昏迷) 是最常见的急性症状 (61.4%),抗精神病药物使用 (59%) 和发烧 (37.6%) 被认为是相关因素.
结论:
- 自从最初的描述以来,科学对SILENT的理解并没有显著地进步.
- 尽管有严格的使用协议,但对SILENT的认识对于预防严重的神经损伤至关重要.
- 需要紧急,全面和标准化的研究来改善对SILENT的理解和管理.
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