静血和肝功能参数作为COVID-19严重性标志物
Qanita Iqbal1, Mudatsir Mudatsir2,3, Harapan Harapan2,3,4,5
1Master Program of Public Health, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.
Narra J
|May 27, 2024
概括
这项研究发现,纤维素和D-二次体水平可以预测COVID-19的严重程度. 监测这些静血标记可能有助于降低患者的死亡率.
科学领域:
- 医学科学 医学科学 医学科学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 冠状病毒疾病2019 (COVID-19),由SARS-CoV-2引起,影响凝血和肝功能.
- 识别可靠的严重性标志物对于管理COVID-19患者至关重要.
- 静血和肝功能参数是疾病严重程度的潜在指标.
研究的目的:
- 研究血液静止和肝功能参数作为COVID-19患者严重性标志物的潜力.
- 评估COVID-19预后特定生物标志物的预测价值.
主要方法:
- 观察性,回顾性队列研究,涉及1208名COVID-19患者.
- 使用曼-惠特尼,后勤回归和ROC分析分析的数据.
- 评估的参数包括血栓细胞计数,前列血时间,aPTT,D-二次体,纤维素原,AST和ALT.
主要成果:
- 与轻度病例相比,严重的COVID-19病例显示血小板计数,PT,aPTT,D-二次数,纤维素原,AST和ALT的水平显著升高.
- 纤维素 (切断值526.5 mg/L) 和D-二次体 (切断值805 ng/mL) 与COVID-19严重程度有显著的关联.
- 结合纤维生素和D-二次体,提高了预测严重程度的灵敏度,达到82.0%.
结论:
- 入院时的纤维素和D-二聚体水平是预测COVID-19预后的宝贵生物标志物.
- 对这些标记物的常规监测可以帮助减少COVID-19的发病率和死亡率.
- 年龄被确定为COVID-19严重程度的最重要的独立因素.
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