炎症和癌症:朋友还是敌人?
Andrés David Turizo-Smith1,2, Samantha Córdoba-Hernandez2, Lidy Vannessa Mejía-Guarnizo3,4
1Doctorado en Oncología, Departamento de Patología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
Frontiers in pharmacology
|May 27, 2024
概括
慢性炎症导致癌症,神经退行性疾病和心血管疾病等疾病. 采用抗炎饮食和探索天然产品提供了有希望的,具有成本效益的癌症预防和治疗策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性炎症是发展各种病理的关键驱动因素,包括神经退行性疾病,心血管疾病,糖尿病,尤其是癌症.
- 很大一部分乳腺癌和结直肠癌与慢性炎症有关,强调需要解决这种联系.
- 肥胖,慢性炎症和癌症之间的相互作用强调了专注于保持健康体重的公共卫生倡议的重要性.
研究的目的:
- 审查病因因子和调解剂在持续性炎症反应和瘤发展中的作用.
- 探索癌症治疗的潜在治疗策略,重点关注癌症相关炎症的经济有效方法.
- 研究天然产品和组合疗法的潜力,作为传统癌症治疗的辅助.
主要方法:
- 关于慢性炎症,癌症病原和治疗干预的研究的文献综述.
- 分析饮食模式,炎症和癌症风险之间的联系.
- 探索药理和基于天然产品的策略,以控制与癌症相关的炎症.
主要成果:
- 饮食炎症指数与癌症风险增加相关,建议抗炎饮食和营养药作为预防措施.
- 天然产品显示出潜在的抗瘤活性,具有有利的安全性,尽管开发面临挑战.
- 使用抗炎药物和植物衍生物产品的组合疗法显示出作为可访问的辅助剂的临床效用.
结论:
- 针对炎症的多因素性质的综合策略对于成功的癌症治疗至关重要.
- 了解遗传变异性,环境因素,饮食和瘤微环境的组成,对于开发向疗法至关重要.
- 对内分泌素,大麻素和前列腺素的进一步研究可能会揭示癌症的新型治疗点和生物标志物.
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