声动力学疗法用于治疗动脉样硬化症
Yan Zhang1, Ying Yang2, Yudi Feng1
1The Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Journal of pharmaceutical analysis
|May 27, 2024
概括
声动力疗法 (SDT) 通过抑制斑块进展和稳定动脉炎症来治疗动脉样硬化 (AS) 是有前途的. 这篇评论详细介绍了SDT.
科学领域:
- 心血管医学 心血管医学
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
背景情况:
- 动脉样硬化 (AS) 是一种慢性炎症性动脉疾病,尽管目前的治疗方法,但死亡率和残疾率很高.
- 声动力疗法 (SDT) 成为AS的一个有希望的非侵入性治疗方法.
- SDT提供局部治疗,以抑制动脉样硬化进展和稳定斑块.
研究的目的:
- 审查用于ASSDT的超声波参数和超声波敏感剂.
- 详细阐述SDT在AS中的治疗效果和机制.
- 讨论安全性,并为AS的未来SDT研究建立框架.
主要方法:
- 审查关于神经动脉样硬化的SDT现有文献.
- 超声波参数和超声波敏感器的分析.
- 关于SDT对动脉样硬化斑块细胞和分子成分的影响的阐述.
主要成果:
- SDT对AS细胞,特别是巨细胞的亡和自产生治疗作用.
- SDT影响巨细胞,T淋巴细胞,新血管化,光滑肌细胞,脂质和斑块内的细胞外基质.
- 讨论了非致命的SDT策略和细胞调节.
结论:
- SDT是一种有前途的非侵入性动脉样硬化疗法,对斑块成分和细胞过程具有既定的影响.
- 需要进一步的研究来优化SDT参数和sonosensitizers用于AS的临床应用.
- 本综述为未来对动脉样硬化的SDT研究提供了一个全面的框架.
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