相关实验视频

Updated: Jun 25, 2025

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

在三阴性乳腺癌中ICAM-1的作用

Ying Zhang¹, Jingjing Fan¹, Xiaoli Wang¹

¹Xinjiang Medical University Affiliated Tumor Hospital, The Clinical Medical Research Center of Breast and Thyroid Tumor in Xinjiang, Urumqi, Xinjiang, 830000, China.

Open medicine (Warsaw, Poland)

|May 27, 2024

概括

细胞间粘附分子-1 (ICAM-1) 在乳腺癌中高度表达,特别是在三阴性乳腺癌 (TNBC) 中. 高ICAM-1水平与TNBC进展,转移和对免疫治疗的反应相关.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

细胞间粘附分子-1 (ICAM-1) 与各种癌症有关.
在三阴性乳腺癌 (TNBC) 亚型中ICAM-1的特定作用,包括生长,转移和预后,需要进一步阐明.

研究的目的:

研究ICAM-1在乳腺癌中的表达和功能,重点关注TNBC亚型.
探索ICAM-1表达和临床结果之间的相关性,包括对免疫治疗的反应和药物敏感性.

主要方法:

在乳腺癌组织和正常组织中对ICAM-1表达的系统生物信息学分析.
检查ICAM-1在乳腺癌和TNBC中激活的途径.
对ICAM-1表达与患者预后,免疫疗法反应和药物敏感性的相关性分析.

主要成果:

与正常组织相比,乳腺癌组织中的ICAM-1表达显著升高,在TNBC中特别高.
在乳腺癌中,ICAM-1 影响了细胞亡和上皮-介质细胞过渡途径.
在TNBC中,ICAM-1过度表达与炎症反应和亡有关,更高的ICAM-1表达预测了更好的免疫治疗反应.
高ICAM-1表达表明对向增殖,亡和血管生成的药物的敏感性.

结论:

乳腺癌表现出显著高的ICAM-1表达,特别是在TNBC亚型中.
在TNBC的诊断,预后,发展,转移和免疫治疗中,ICAM-1表达是关键因素.
这项研究为推进TNBC的诊断和治疗策略提供了有价值的数据.

关键词:

在 ICAM-1 中,生物标志物生物标志物免疫疗法免疫疗法癌症基因组地图,癌症基因组地图.三重阴性乳腺癌是什么

更多相关视频

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

The Use of Mouse Mammary Tumor Cells in an In Vitro Invasion Assay as a Measure of Oncogenic Cell Behavior

The Use of Mouse Mammary Tumor Cells in an In Vitro Invasion Assay as a Measure of Oncogenic Cell Behavior

Published on: June 12, 2019

相关概念视频

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...