揭示癌症景观中的内微生物群
Shusheng Che1, Zhiyong Yan1, Yugong Feng1
1Department of Neurosurgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266005, Shandong, China.
iScience
|May 27, 2024
概括
内微生物群,包括瘤内的细菌,真菌和病毒,显著影响癌症的发展和治疗. 了解这些微生物为癌症提供了新的诊断和治疗策略.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 癌症生物学 癌症生物学
背景情况:
- 内微生物群,包括瘤组织内的细菌,真菌和病毒,代表了癌症研究的重要领域.
- 这些微生物群体越来越多地被认为对瘤发育,进展和治疗反应的影响.
研究的目的:
- 综合最近关于癌症内微生物群的发现.
- 提供关于它们的识别,表征和功能角色的综合概述.
- 阐明瘤内微生物与瘤微环境之间的相互作用.
主要方法:
- 关于癌症研究近期进展的文献评论.
- 对内微生物群的识别和表征数据的综合.
- 分析瘤微环境中的功能角色和相互作用.
主要成果:
- 内微生物群显著影响瘤的发展和进展.
- 这些微生物影响了癌症治疗干预措施的有效性.
- 在内微生物群和瘤微环境之间存在复杂的相互作用.
结论:
- 内微生物群是癌症生物学中一个关键的,但被低估的维度.
- 这些微生物群落有可能成为癌症诊断的新生物标志物.
- 向内微生物群可能为癌症治疗提供创新的治疗策略.
相关概念视频
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K


