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Updated: Jun 25, 2025

The Lactate Dehydrogenase Sequestration Assay — A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells
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与ALS相关的C9orf72二重复物通过调节BCL2-BECN1相互作用来抑制饥饿诱导的自

Shiqiang Xu1, Qilian Ma1,2, Junwen Shen1

  • 1Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.

Acta pharmaceutica Sinica. B
|May 27, 2024
PubMed
概括

来自C9orf72基因突变的二重复 (DPR) 抑制了细胞的关键过程 - - 自. 这种功能障碍会损害有毒蛋白质的清除,导致ALS和FTD的神经退行.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.自自是一种自的过程.在BCL2中,BCL2是BCL2.BECN1/Beclin 1 贝克林 1 贝克林 1 贝克林 1 贝克林C9orf7272 是一个很好的方法.滴重复的重复在前性痴呆症.神经退行发生神经退行.

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