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Updated: Jun 25, 2025

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

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通过组装理论和光谱学研究和量化分子复杂性

Michael Jirasek1, Abhishek Sharma1, Jessica R Bame1

  • 1School of Chemistry, The University of Glasgow, University Avenue, Glasgow G12 8QQ, U.K.

ACS central science
|May 27, 2024
PubMed
概括

研究人员开发了一种方法,使用光谱学实验测量分子复杂性. 这种方法量化了分子组合,为分子进化和药物发现提供了新的见解.

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Analyzing Large Protein Complexes by Structural Mass Spectrometry

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Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies10:01

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
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