纳米粒子介导的协同化学免疫疗法用于癌症治疗
Xiaoxue Lang1, Xiangtao Wang1, Meihua Han1
1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
International journal of nanomedicine
|May 27, 2024
概括
化疗免疫疗法 (CIT) 在癌症治疗方面表现有前途. 基于纳米的药物递送系统 (NDDS) 通过向癌症和免疫细胞来增强CIT,提高疗效和降低毒性.
科学领域:
- 在瘤学瘤学.
- 纳米技术 纳米技术
- 免疫学 免疫学 免疫学
背景情况:
- 癌症治疗面临的挑战是单一疗法的有效性有限.
- 免疫疗法具有潜力,但需要加强以获得更广泛的应用.
- 化疗免疫疗法 (CIT) 结合了化疗和免疫疗法,以改善结果.
研究的目的:
- 审查目前的免疫疗法和化疗的免疫调节作用.
- 探索纳米药物输送系统 (NDDS) 在CIT中的作用.
- 讨论NDDS在化疗免疫治疗中的协同作用潜力.
主要方法:
- 对五种主要免疫疗法的审查:免疫检查点阻断 (ICB),采用细胞转移 (ACT),癌症疫苗,型病毒疗法 (OVT) 和细胞因子疗法.
- 分析化疗对调节瘤免疫微环境的机制,包括免疫细胞死亡 (ICD).
- 详细检查NDDS在CIT中的目标交付和协同效应.
主要成果:
- 免疫疗法具有多种机制来吸引免疫系统对抗癌症.
- 化疗可以通过ICD,免疫细胞透和免疫抑制因子调节来增强抗瘤免疫力.
- NDDS促进化学疗法和免疫疗法剂的同时递送,改善药物积累并降低全身毒性.
结论:
- CIT,特别是当被NDDS增强时,代表了有效治疗癌症的有希望的策略.
- NDDS提供了一个开发先进化学免疫疗法纳米粒子的平台,具有有针对性的交付和协同作用.
- 进一步开发NDDS介导的CIT对于克服当前治疗局限性至关重要.
更多相关视频
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
10.9K
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.1K
相关概念视频
01:27Tumor Immunotherapy
515
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
515
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:30Cancer Vaccines
355
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
355
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K