醒着的海的听觉皮层的音色组织是由多模态广场光学成像揭示的
Xindong Song1,2,3,4, Yueqi Guo1, Chenggang Chen1
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Current research in neurobiology
|May 27, 2024
概括
研究人员绘制了清醒的海的听觉皮层,揭示了新的音色梯度. 这项研究提供了关于灵长类动物听觉皮层组织的详细见解,挑战了现有的模型.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 灵长类的神经生物学
背景情况:
- 听觉皮层的音色组织在哺乳动物中得到了很好的研究.
- 灵长类动物听觉皮层的映射受到皮层折叠,麻醉和方法的限制.
研究的目的:
- 为了全面地绘制清醒灵长类动物听觉皮层中的音量结构.
- 为了研究超越标准模型的新色度梯度.
主要方法:
- 综合内在光学信号成像 (通过头骨和窗口),广场成像和神经探测器记录.
- 利用醒着的海 (Callithrix jacchus) 具有更平坦的大脑表面,以改善成像.
- 经过验证的成像结果与单个单位记录和成像.
主要成果:
- 揭示了粗的音位梯度,包括面向时间梯度 (RT) 到带梯度.
- 确定了一个额外的,以前未被描述的色度梯度,从面向面积RT.
- 提供了详细的拓地图,在一个清醒的灵长类动物中前所未有的面向覆盖.
结论:
- 灵长类动物的听觉皮层表现出一个尾部 - 部中等尺度组织,至少有三个功能梯度重复.
- 这些发现挑战了灵长类动物听觉皮层音位组织的标准模型.
- 结果提供了关于清醒灵长类动物听觉皮层色谱的全面数据.
更多相关视频
07:52Author Spotlight: Investigating Vocal Information Representation in Small Primates and Its Alteration by Psychiatric Disorders Using Noninvasive EEG
Published on: July 26, 2024
664
07:52Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
Published on: May 23, 2025
120
相关概念视频
Hearing
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Hair Cells
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Perception of Sound Waves
The human ear is not equally sensitive to all frequencies in the audible range. It may perceive sound waves with the same pressure but different frequencies as having different loudness. Moreover, the perception of sound waves depends on the health of an individual's ears, which decays with age. The health of one's ears may also be affected by regular exposure to loud noises.
The pitch of a sound depends on the frequency and the pressure amplitude of the source. Two sounds of the same frequency...
The pitch of a sound depends on the frequency and the pressure amplitude of the source. Two sounds of the same frequency...
Sound as Pressure Waves
Sound waves, which are longitudinal waves, can be modeled as the displacement amplitude varying as a function of the spatial and temporal coordinates. As a column of the medium is displaced, its successive columns are also displaced. As the successive displacements differ relatively, a pressure difference with the surrounding pressure is created. The gauge pressure varies across the medium.
The pressure fluctuation depends on the difference in displacements between the successive points in the...
The pressure fluctuation depends on the difference in displacements between the successive points in the...
Perceiving Loudness, Pitch, and Location
The human brain perceives pitch through two primary mechanisms reflected in place theory and frequency theory. Each mechanism describes how sound waves are interpreted as specific pitches by the brain, offering insights into the intricate processes of auditory perception.
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by identifying...
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by identifying...
