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与非特异性免疫抑制剂相比,二甲基烟酸的比较有效性:来自MSBase的真实世界证据

Tim Spelman^1,2, Sara Eichau³, Raed Alroughani⁴

¹MSBase Foundation, Melbourne, Australia.

Multiple sclerosis journal - experimental, translational and clinical

|May 27, 2024

概括

与多发性硬化症 (MS) 的非特异性免疫抑制剂 (NSIS) 相比,二甲基烟酸 (DMF) 的复发率相似,但在停止治疗,残疾进展和改善方面表现更好. 这支持DMF在复发性MS中使用.

科学领域:

神经学神经学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

尽管存在安全问题,但全球范围内对多发性硬化症 (MS) 仍然广泛使用非特异性免疫抑制剂 (NSIS).
资源限制可能会导致某些地区继续使用NSIS.

研究的目的:

为了比较二甲基烟酸 (DMF) 与成年复发性复发性多发性硬化症 (RRMS) 的NSIS的现实结果.
评估疗效和安全终点,包括复发率,停药和残疾进展/改善.

主要方法:

使用MSBase注册表数据从2014年1月1日到2022年4月1日.
用治疗权重的逆概率 (IPTW) 考克斯回归来进行结果比较.
评估年度复发率 (ARR),停药时间,首次复发时间 (TTFR) 和确认残疾进展 (CDP) 或改善 (CDI) 的时间.

主要成果:

在DMF (0.13) 和NSIS (0.16) 组之间,ARRs是相似的 (p=0.29).
没有观察到TTFR的显著差异 (HR:0.98;p=0.84).
与NSIS相比,DMF的停药时间显著更长 (HR: 0.75; p=0.001) 和CDP (HR: 0.53; p=0.001),CDI的时间更短 (HR: 1.99; p<0.008).

结论:

与NSIS相比,二甲基烟酸 (DMF) 是MS复发形式的可行的治疗选择,在关键领域表现出较好的结果.
这些发现可能会影响在RRMS管理中NSIS仍然是常见的选择的地区的MS治疗指南.

关键词:

甲基二甲烟酸二甲烟酸二甲烟酸二甲烟酸二甲烟酸二甲有效性有效性.非特异性免疫抑制剂非特异性免疫抑制剂现实世界的真实世界.复发性复发性复发性多发性硬化症

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