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Updated: Jun 29, 2026

Models of Bone Metastasis
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IL-1B在乳腺癌骨转移中的作用

Jiabao Zhou1, Penelope D Ottewell1

  • 1Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom.

Journal of bone oncology
|May 27, 2024
PubMed
概括

干白素-1B (IL-1B) 通过创造支持性的微环境来驱动乳腺癌骨转移. 抑制IL-1信号传递是有前途的,特别是与其他疗法结合使用时.

关键词:
骨转移的发生.乳腺癌是什么? 乳腺癌是什么?介质蛋白-1BB 介质蛋白-1B 介质蛋白-1B 介质蛋白

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...