缓解骨瘤:生物活性玻璃和心周膜组合在老鼠模型中
Alexandre Antonio Pellicano1, Bernar M Benites1, Amanda F N Paschoa1
1Laboratory of Neuroscience, Hospital Sírio-Libanês, São Paulo, SP, Brazil.
Frontiers in oncology
|May 27, 2024
概括
生物活性玻璃和心周膜在双酸盐相关骨缩的临床前模型 (BRONJ) 中有效地预防了骨缩. 这种组合疗法对管理与双酸盐治疗相关的并发症有前途.
科学领域:
- 生物材料科学 生物材料科学
- 口腔和牙面部外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 双酸盐 (BFs) 对于治疗骨质疏松症和骨转移至关重要.
- 与双酸盐相关的骨死 (BRONJ) 是与BFs相关的重大风险.
- 目前的BRONJ治疗缺乏黄金标准,强调减轻症状.
研究的目的:
- 在临床前的BRONJ模型中评估生物活性玻璃和/或心周膜的预防效果.
- 评估这些材料在酸治疗动物的牙抽取后预防骨髓缩和骨损失的潜力.
主要方法:
- 老鼠接受了龙酸 (ZA) 或盐水,随后进行了下骨提取.
- 心周膜,有或没有F18生物玻璃,在提取后被应用.
- 微CT,PET成像与18F-FDG和18F-NaF,以及组织学被用于分析.
主要成果:
- ZA治疗导致了显著的膜骨损失,骨髓缩和提取后的感染.
- 同时使用心周膜和F18生物玻璃可以防止这些不良结果.
- 在接受膜的ZA治疗的老鼠中,PET成像表明提取部位的葡萄糖代谢增加.
结论:
- 周心膜与F18生物玻璃相结合,在临床前环境中显示出针对BRONJ的显著预防作用.
- 这种组合疗法有可能减轻双酸盐治疗的患者的BRONJ并发症.
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