在固体瘤中出现骨转移的发生率和危险因素
Brendan J Knapp1, Giordano F Cittolin-Santos1, Mary E Flanagan1
1Department of Medicine, Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, United States.
Frontiers in oncology
|May 27, 2024
概括
骨转移在肺癌,前列腺癌,乳腺癌和癌中很常见. 识别格里森评分和HER2状态等预测因素可以帮助针对高风险患者进行早期干预.
科学领域:
- 在瘤学瘤学.
- 癌症转移研究 癌症转移研究
- 流行病学 流行病学
背景情况:
- 骨转移会显著增加癌症患者的发病率,降低癌症患者的生活质量.
- 早期识别患有骨转移风险的患者对于及时干预至关重要.
- 了解发病率和预测因素可以为临床决策提供信息.
研究的目的:
- 为了追溯确定大量人群的初始诊断时骨转移的发病率.
- 确定关键的人口和瘤特异性骨转移的预测因素.
- 分析这些因素在一组多样化的固体瘤患者中.
主要方法:
- 使用了监测,流行病学和最终结果 (SEER) 数据库 (2010-2019).
- 包括成年患者 (≥18岁) 患有固体瘤,不包括血液恶性瘤和原发性骨瘤.
- 根据人口和临床特征计算发病率和分析预测因素.
主要成果:
- 在1,075,070名符合条件的患者中,5.2%的人发现骨转移.
- 最常见的初级瘤转移到骨:肺 (44.4%),前列腺 (19.3%),乳腺 (12.3%),脏 (4.0%).
- 确定的预测因素包括格里森评分 (前列腺),HER2/HR状态 (乳腺),组织学 (肺),肝转移 (结肠直肠).
结论:
- 骨转移在呈现时很普遍,特别是在肺癌,前列腺癌,乳腺癌和癌中.
- 特定的临床和病理因素与骨转移的风险增加有显著的关联.
- 这些发现强调了在诊断时考虑转移风险的重要性.
相关概念视频
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K


