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脑垂体-甲状腺激素轴和甲状腺结节的发育变化之间的性别特异性关联在中国甲状腺成年人中:基于社区的横截面研究

Ying Li¹, Genfeng Yu¹, Nanfang Yao^1,2

¹Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, China.

Frontiers in endocrinology

|May 27, 2024

概括

甲状腺激素 (TH) 的作用和甲状腺结节 (TN) 的患病率在成年人中显示出性别特异的模式. 较低的TSH,FT3和FT4反敏感性与女性中较高的TN患病率有关,在男性中有一些关联.

科学领域:

内分泌学在内分泌学.
甲状腺学甲状腺学
公共卫生公共卫生

背景情况:

以前的研究强调了特定于性别的甲状腺垂体激素 (TH) 作用和年轻人群中的甲状腺结节 (TN) 患病率.
在成年人中,这些因素之间的关系仍然不清楚,需要进一步调查.

研究的目的:

为了研究成年人脑下垂体TH作用的年龄和性别特异性模式.
检查甲状腺激素 (TSH),甲状腺激素和中部甲状腺激素敏感度指数 (TFQI_FT4,TFQI_FT3) 与中国甲状腺敏感度指数之间的关联.

主要方法:

一项涉及8771名来自中国社区的非甲状腺成年人的研究.
数据收集包括人口统计,行为,人体测量和TNS的超声波.
测量了TSH和THs水平,并进行了多变量逻辑回归分析.

主要成果:

在TSH,THs,TFQI_FT4和TFQI_FT3方面观察到年龄和性别相关的趋势.
较低的TSH水平与两性中较高的TN患病率相关.
较低的TFQI_FT3和TFQI_FT4与女性更高的TN患病率有关,而男性的TFQI_FT3较低.

结论:

pituitary-TH轴动态和TN形成在成年人中表现出性别特异性关系.
TFQI_FT4和TFQI_FT3与女性的TN患病率和数量有负相关性.
这些发现提高了对影响甲状腺结节发育的性别特异性因素的理解.

关键词:

第十一条关于TFQI的规定下垂体 - 甲状腺激素轴对甲状腺激素的敏感性性别特定的性别特定的性别.甲状腺结节甲状腺结节

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