对荷尔蒙和生殖因素与腰部疼痛之间的相关性进行因果关系检查
Dafu Chen1, Jiaxiang Zhou2, Chengkai Lin3
1Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
Frontiers in endocrinology
|May 27, 2024
概括
早期的生殖里程碑,如初潮和初胎,可能会降低腰部疼痛 (LBP) 的风险. 这项研究使用了门德尔的随机化来探索女性生殖因素和LBP之间的因果关系.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 激素波动和生殖因素与腰部疼痛 (LBP) 有关.
- 特定因素,如初潮时的年龄 (AAM) 和第一次分娩时的年龄 (AFB) 对LBP的因果影响尚不清楚.
研究的目的:
- 使用孟德尔随机化研究激素和生殖因素与LBP之间的因果关系.
- 评估生殖因素对LBP风险的直接因果影响,根据BMI进行调整.
主要方法:
- 双向门德尔随机化 (MR) 使用GWAS和FinnGen联盟数据.
- 采用逆变量加权 (IVW),MR-Egger回归和加权中位数方法.
- 进行了灵敏度分析和多变量孟德尔随机化 (MVMR).
主要成果:
- 与初潮早期年龄 (AAM),第一次分娩年龄 (AFB),最后一次活产年龄 (ALB) 和第一次性交年龄 (AFS) 相关的LBP风险降低.
- 没有观察到LBP对更年期年龄 (ANM),AAM,月经周期长度 (LMC) 或AFS的显著因果作用.
- MVMR证实了AFB对LBP的显著因果作用,独立于BMI.
结论:
- 早期的AAM,AFB,ALB和AFS可能会降低LBP风险.
- 调查结果提供了对女性LBP风险因素的见解.
- 结果可以为LBP的查,预防和治疗策略提供信息.
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