定期使用鱼油补充剂和心血管疾病的过程:前性队列研究
Ge Chen1, Zhengmin Min Qian2, Junguo Zhang1
1Department of Epidemiology, Sun Yat-Sen University, Guangzhou, China.
BMJ medicine
|May 27, 2024
概括
鱼油补充剂可能会增加健康个体心房动和中风的风险. 然而,它们可能会通过减少主要不良事件和死亡率,使已有心血管疾病的人受益.
科学领域:
- 心血管医学 心血管医学
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病仍然是全球死亡的主要原因.
- 鱼油补充剂被广泛用于感知到的心血管益处.
- 鱼油在心血管疾病 (CVD) 进展中的作用尚未完全理解.
研究的目的:
- 调查鱼油补充剂使用与心血管疾病的临床过程之间的关联.
- 研究鱼油对从健康状态过渡到心房动,主要心血管不良事件 (MACE) 和死亡的影响.
主要方法:
- 一项前性队列研究,利用来自英国生物库的数据.
- 包括415,737名年龄在40-69岁之间的参与者,随访时间为2021年3月.
- 通过记录链接确定了心血管事件和死亡事件.
主要成果:
- 在没有事先存在心血管疾病的患者中,定期使用鱼油与心房动 (HR 1.13) 和中风 (HR 1.05) 的风险增加有关.
- 对于患有心血管疾病的人来说,鱼油使用在降低心房动 (HR 0.92) 和心力衰竭死亡率 (HR 0.91) 后的MACE方面显示出好处.
结论:
- 在一般人群中,鱼油补充剂可能是心房动和中风的危险因素.
- 相反,鱼油可以在患有已确定的心血管疾病的患者中提供对不良结果的保护作用.
- 需要进一步的研究来阐明这些差异性影响背后的机制.
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