与临床显著的气道缺血相关的危险因素,发生率和结果
Gloria Li1, Zejian Liu2, Marcelo Salan-Gomez3
1Department of Medicine, Baylor College of Medicine, Houston, TX, United States.
概括
呼吸道缺血 (CSAI) 影响了超过三分之一的肺移植接受者,导致狭窄,衰退和生存率降低. 优化气道缩治疗可能会减少这种严重的并发症.
科学领域:
- 移植手术 移植手术
- 肺部医学 肺部医学
- 手术并发症 手术并发症
背景情况:
- 呼吸道并发症是肺移植后发病和死亡的主要原因.
- 临床显著的气道缺血症 (CSAI) 在肺移植接受者中构成重大挑战.
研究的目的:
- 确定肺移植患者中CSAI的发病率,风险因素和结果.
- 分析导致气道缺血的因素及其对患者生存的影响.
主要方法:
- 从2016年2月到2020年12月,对217例肺移植 (386例气道解剖) 的回顾性审查.
- 使用修改的2018年ISHLT分级来评估气道缺血.
- 回归分析确定了与CSAI相关的风险因素和结果.
主要成果:
- CSAI的发生率为37.8% (82名患者).
- CSAI与较低的一年 (80.5% vs. 91.9%) 和三年 (67.1% vs. 77.8%) 的生存率相关.
- 风险因素包括接受者的年龄较小,糖尿病,单步技术和下静脉氧和.
结论:
- 呼吸道缺血仍然是肺移植的重大障碍.
- 与手术技术和患者生理学相关的因素影响CSAI的发展.
- 改善气道瘤的愈合对于减轻CSAI风险至关重要.
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