在多个生物测量和认知表现和心血管疾病风险的访问到访问的变化:一个队列研究
Laura Sherlock1,2, Shun Fu Lee2, Tali Cukierman-Yaffe3,4
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Cerebral circulation - cognition and behavior
|May 27, 2024
概括
血压,心率,体重和葡萄糖的访问到访问的变化与认知功能恶化和心血管疾病 (CVD) 风险增加有关. 具有高可变性的多种生物测量结果显示,对认知和心血管疾病的结果产生了附加的负面影响.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 代谢健康 代谢健康
背景情况:
- 单个生物标志物的访问对访问的变化与认知衰退和心血管疾病 (CVD) 有关.
- 跨多种生物指标的变异性对健康结果的影响仍未得到充分研究.
- 这项研究研究了关键生理参数和认知/心血管健康的访问到访变异性之间的关联.
研究的目的:
- 为了研究血压 (BP),心率 (HR),体重,禁食血葡萄糖 (FPG),胆固醇和甘油三在认知表现上的访问对访问变化的影响.
- 评估这些生物指标的访问-访问变异性与心血管事件风险之间的关联.
- 为了确定多个措施中高变量的影响是否是累积的.
主要方法:
- 利用了ORIGIN试验的数据,分析了BP,HR,体重,葡萄糖,胆固醇和甘油三.
- 为每个参与者计算访问到访问的标准偏差,并测量量变化.
- 根据具有高可变性 (最高四分位数) 的测量数量进行分类,并使用回归/生存模型进行分析.
主要成果:
- 在BP,HR,体重和FPG中,访问对访问的变化增加与较差的认知得分 (Mini Mental State Examination - MMSE) 和更高的心血管疾病风险有关.
- 高可变性的影响是附加的;具有≥4个高度可变度的个体显示MMSE得分明显较差,心血管疾病风险明显较高,与没有高可变性的个体相比.
- 单个测量的效应大小是可比的.
结论:
- 在多种生物测量中,访问对访问的变化累计与较差的认知表现有关.
- 在几个生理参数中,访问到访问的变异性增加显著增加了心血管事件的风险.
- 管理生物标志物的变异性可能对改善认知和心血管健康结果至关重要.
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