饮食中的血红素补充可以恢复由草鱼 (Ctenopharyngodon idella) 的高脂肪饮食引起的肌肉质量和营养成分的下降
Yong Shi1,2,3, Lei Zhong1,2, Yuanxiang Liu1,2
1Fisheries College, Hunan Agricultural University, Changsha, 410128, China.
Animal nutrition (Zhongguo xu mu shou yi xue hui)
|May 27, 2024
概括
血红素补充改善了草的生长和肌肉质量,抵消了高脂肪饮食的负面影响. 这种天然化合物增强脂肪代谢,减少炎症,为水产养殖提供了有前途的解决方案.
科学领域:
- 水产养殖营养水产养殖营养
- 动物生理学 动物生理学
- 生物化学 生物化学
背景情况:
- 高脂肪饮食 (HFD) 对水生动物的肌肉质量产生负面影响.
- 众所周知,sanguinarine可以减少脂肪沉积和炎症.
- 血红素对HFD诱导的肌肉质量下降的影响尚不清楚.
研究的目的:
- 为了研究饮食中的血红素补充剂对草的影响,食高脂肪饮食.
- 评估血红素对草的生长性能,肌肉质量,脂肪代谢和炎症的影响.
主要方法:
- 进行了一项为期8周的草鱼 (Ctenopharyngodon idellus) 养试验.
- 鱼类被食基本饮食 (CON) 或高脂肪饮食 (HFD),有或没有血 (HFDS).
- 使用单向ANOVA和Duncan的多重比较分析了生长性能,肌肉组成,基因表达 (脂肪代谢,蛋白质合成,炎症,氧化应激) 和肌肉硬度.
主要成果:
- HFD显著减少了生长,蛋白质沉积,肌纤维直径和肌肉硬度,同时增加了脂肪沉积和炎症.
- 血红素补充剂 (HFDS) 改善了生长,脂肪代谢 (上调ppar-α,lpl,atgl,cpt1) 和蛋白质沉积 (上调AKT,PI3K,TOR,P70S6K).
- 此外,HFDS还增加了肌纤维直径,肌肉硬度和必需脂肪酸,同时通过降低nf-κb,il-1β,il-6,il-8,tnf-α和升高nrf2,gpx4,cat,sod,gr.的调节来减少氧化损伤.
结论:
- 血红素补充剂有效地减轻了高脂肪饮食对草生长和肌肉质量的不良影响.
- 桑圭纳林可以增强脂肪代谢和蛋白质合成途径,同时减轻炎症和氧化应激.
- 这些发现为在水产养殖中使用血红素作为料添加剂提供了理论依据,以改善鱼类健康和产品质量.
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