儿科人口中的良性过渡性高酸血症:单一中心队列研究
Gonul Buyukyilmaz1, Serkan Bilge Koca2, Banu Turhan1
1Department of Pediatric Endocrinology, Ankara Bilkent City Hospital, Ankara, Türkiye.
概括
良性过渡性酸盐高血症 (BTH) 是儿童酸酶 (ALP) 升高的常见原因. 这种情况通常在几周内消失,通常与感染有关,不需要特殊治疗.
科学领域:
- 儿科 儿科 儿科
- 临床化学 临床化学
- 生物化学 生物化学
背景情况:
- 儿童血清性酸酶 (ALP) 升高可能表明各种疾病,包括肝脏和骨疾病.
- 良性过渡性高酸血症 (BTH) 是一种已知的,尽管不太常见的,导致ALP升高的原因.
- 了解BTH特征对于准确诊断和避免不必要的调查至关重要.
研究的目的:
- 研究被诊断患有BTH的婴儿和儿童的人口和临床特征.
- 描述BTH儿童的ALP水平及其正常化模式.
主要方法:
- 在2019年9月至2023年9月期间诊断出BTH的婴儿和儿童的回顾性分析.
- 评估人口统计数据,初始和后续的ALP水平,以及正常化时间.
主要成果:
- 在249名高ALP儿童中,95名 (38.1%) 被诊断为BTH.
- 诊断的平均年龄为2.4岁,ALP水平平均为正常的上限的7.4倍.
- 在13天内,ALP水平下降了61%,大约44天后恢复正常;51.6%的病例发生在感染期间.
结论:
- 在患有血清ALP升高的儿科病例中应考虑BTH,特别是当不怀疑骨或肝脏疾病时.
- 随访期间ALP水平显著下降的趋势支持BTH的诊断.
- 区分BTH与高酸盐血症的其他原因对于适当的临床管理至关重要.
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